Description
Subchronic toxicity is the test that continues after the acute toxicity test. The difference between the two tests is the duration of time the substances are exposed to. Subchronic toxicity requires more time than acute toxicity. The amount of time required for exposure based on the duration of the substance’s use in humans.The purpose of the chronic toxicity test is to identify hazardous effects that may arise from repeated oral or dermal exposure over a short period of time during half of life expectancy, but not more than 10% of life. In addition, the test’s goal is to learn about the likelihood that toxic effects may manifest themselves that are not observable in acute toxicity tests, the dose at which there are no toxic effects (known as the NOAEL), as well as the cumulative impact and reversibility of such chemicals. The safety of the product in accordance with current regulations is the ultimate goal of all efforts.

How can SIG help?
As an authorized toxicity testing facility, SIG may conduct subchronic toxicity testing on a variety of pharmaceutical products, traditional medicines, cosmetics, and pesticides in accordance with all pertinent guidelines.

Method of Analysis
The Indonesian government has provided us with toxicity criteria, which we follow when conducting the testing. These standards include

1. BPOM Regulation (Drugs, traditional medicine, and cosmetics)
2. Toxicity guidance by Directorate of Fertilizer and Pesticides (Pesticides)